বুধবার, ২৪ অক্টোবর, ২০১২

Melanie Griffith: People tell me 'I look horrible'

By Us Weekly

Richard Shotwell / AP

Melanie Griffith at the Children's Hospital LA Gala: Noche de Ninos at L.A. Live on Saturday, Oct. 20.

Haters gonna hate. Melanie Griffith knows this all too well. Posing for photographs at the Oct. 20 Children's Hospital of Los Angeles Gala: Noche de Ninos, the Oscar-nominated star looked slim and sexy in a strapless, curve-hugging floral gown by Dolce & Gabbana, with Miu Miu platform sandals, red lips, and a tousled up-do.?

PHOTOS: Hollywood families?

But it seems not everyone thinks the 55-year-old blonde is aging well. Us Weekly caught up with Griffith on the red carpet, where she revealed that folks on Twitter have had some not-so-nice things to say about her appearance of late.?

"Most people are telling me I look horrible," the "Working Girl" actress told Us. "The tweets I get are really nasty."?

PHOTOS: Ageless A-listers?

Still, the star -- whose daughter Dakota Johnson stars in the new Fox sitcom "Ben & Kate" -- appeared to be in good spirits all night. She worked the room like a pro, smiling and laughing as she chatted with husband Antonio Banderas, pal Jamie Lee Curtis, and supermodel Heidi Klum, who received a "Courage to Care" award from the hospital.?

PHOTOS: Dakota and other rising stars?

So what's the secret to Griffith's composure in the face of criticism? Modesty. And exercise.?

"I don't know if I look that great," she demurred. "[But] I work out a lot. I have a trainer that I [work with] four times a week, and I do hot yoga." ?

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Source: http://todayentertainment.today.com/_news/2012/10/22/14624885-melanie-griffith-people-tell-me-i-look-horrible?lite

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Random shootings prompt school lockdowns in Mich.

WIXOM, Mich. (AP) ? Kids were kept off school playgrounds Monday and some commuters changed their routes as police searched for a suspect in 20 random shootings that have mostly damaged vehicles on busy roads across four Michigan counties.

No one has been hurt, and no shootings have occurred since Thursday. But police on Monday added to their list two more incidents from the small city of Perry, off U.S. 69, stretching the investigation to four counties, Oakland County Undersheriff Mike McCabe said.

Tipsters told police the gunman appears to be a man in his 30s and authorities on Sunday released a drawing of a possible suspect with close-cropped hair and stubble on his cheeks and chin. While the incidents appear to be random, police are investigating them as a pack and have formed a task force to chase down tips.

The shootings mostly involve cars near Interstate 96, though authorities have said one occurred while a man was taking out his garbage. In another incident, a woman said the rear window on her car was shattered. Ten of the 20 shootings have occurred in Wixom, 35 miles northwest of Detroit.

In the Walled Lake district, officials felt compelled to lock doors at five schools in Wixom and hold recess indoors on a beautiful fall day, though there is no evidence schools are a target. They're not sure how long the policy will be in effect.

"We want all our students and families to feel safe. These are precautionary measures," school spokeswoman Judy Evola said.

The shootings were a hot topic on morning drive-time radio shows with listeners calling or texting their plans to avoid I-96 in certain areas.

"You can never be too careful, obviously," McCabe said. "Until this guy or suspects are found, people need to be aware of their surroundings. There is nothing wrong with taking precautions. We're not going to tell people they're overreacting."

The shootings have occurred in Oakland, Livingston, Ingham and Shiawassee counties, from last Tuesday through Thursday.

___

Ed White in Detroit contributed to this report.

Source: http://news.yahoo.com/michigan-roadway-shootings-prompt-school-lockdowns-172300135.html

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DEER VALLEY REAL ESTATE MARKET UPDATE

DEER VALLEY REAL ESTATE MARKET UPDATE ? Supply and demand has recently come back more or less into balance with respect to Deer Valley area condominiums.? With the exception of the lower Deer valley area (Snow Park), where the supply is slightly longer than a year, in both upper Deer Valley (Silver Lake) and Empire Pass, the supply is down to a year or less.

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Upper Deer Valley Condominiums ? 33 Active Listings for Sale 37 Pending or Closed Sales in last 12 months.

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Empire Pass Deer Valley Condominiums - 31 Active Listings for Sale 31 Pending or Closed Sales in last 12 months.

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Lower Deer Valley Condominiums ? 53 Active Listings for Sale 38 Pending or Closed Sales in last 12 months.

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Source: http://deervalleyluxuryrealty.com/real-estate-news/deer-valley-real-estate-market-update/

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Technology brings new life to the study of diseases in old bones

ScienceDaily (Oct. 22, 2012) ? A study led by The University of Manchester has demonstrated that new technology that can analyse millions of gene sequences in a matter of seconds is an effective way to quickly and accurately identify diseases in skeletons.

Professor Terry Brown, working in partnership with Professor Charlotte Roberts from Durham University, used a next generation sequencing approach, including hybridization capture technology, to identify tuberculosis genes in a 19th century female skeleton found in a crypt in Leeds.

Their study is part of wider research into the identification of strains of TB in skeletons dating from 100 AD to the late 19th century. It's hoped that understanding how the disease has evolved over time will help improve treatments and vaccines. TB rates have been increasing around the world, and it's estimated that one third of the world's population has latent TB. After HIV it kills more people than any other infectious disease.

Certain strains of TB affect the sufferer's bones, especially in the spine. The marks made by the disease remain evident on the bones long after the person's death. It's this evidence that Professor Roberts used to find suitable skeletons to screen for tuberculosis genes.

She sourced 500 skeletons from across Europe that showed evidence of TB dating from the Roman period to the 19th century. Bone samples from these skeletons were screened for TB DNA, and of those 100 were chosen for this particular study.

Professor Roberts explains: "So many skeletons were needed as it's very hard to tell if any DNA will have survived in the bones. You don't really know if there will be any present until you start screening and in the past that has been a lengthy process."

Professor Terry Brown then took on the search for TB DNA in the skeletons. Each small section of bone was ground up and placed in a solution. That was then put in a special machine which captured every gene sequence in the DNA. Millions of sequences were captured and sent to a computer.

Professor Brown and his team then searched for the gene sequences for tuberculosis. Because it is a bacterial disease the bacteria's DNA can remain in the bones after death.

Talking about the process Professor Brown said: "Previously we could only scan the bone sample for specific genes. We wouldn't see everything that was there which meant we could easily miss other genetic information that could be relevant. Using the hybridization screening meant we could search for different strains of TB, not just one."

About 280 bits of sequence in the DNA were found to match known tuberculosis genes. The data placed the historic strain of TB in a group that is uncommon today, but was known to have been present in North America in the 19th century. In fact it was found to be very similar to a strain recorded in a tuberculosis patient in New York in 1905.

Discussing the results Professor Brown says: "The fact that this particular strain of TB was found in both North America and in the skeleton from 19th century Yorkshire is not necessarily unusual. There were many migrants from Britain to America during the 19th century so it makes sense that TB strains were spread."

One of the downsides of hybridization capture identified by the researchers in this study was that it is possible to mistakenly identify DNA. Because it looks at all the sequences across the sample it may identify DNA that isn't from the bone, but actually from the surrounding soil or environment where the skeleton was buried.

In this study the results were checked using the more traditional method of polymerase chain reactions and were found to be accurate. The researchers concluded that using hybridization capture and next generation gene sequencing is an accurate and effective way to obtain detailed genotypes of ancient varieties of tuberculosis. It could potentially be used to study other diseases. Their findings have been published in the journal The Proceedings of the National Academy of Sciences.

Professor Roberts says: "We're really pleased with the results of this study and that the technology works. It will save a lot of time in the future. We now hope to publish more of the huge amounts of data we have acquired from the sequencing"

The scientists hope to compare their results with similar studies being done in America to assess what tuberculosis strains have been identified there. They're interested in studying which strains were brought to the country by migrants and what impact those had on the native strains of the disease.

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The above story is reprinted from materials provided by University of Manchester, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Abigail S. Bouwman, Sandra L. Kennedy, Romy M?ller, Richard H. Stephens, Malin Holst, Anwen C. Caffell, Charlotte A. Roberts, and Terence A. Brown. Genotype of a historic strain of Mycobacterium tuberculosis. PNAS, October 22, 2012 DOI: 10.1073/pnas.1209444109

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/9Mm4InrBnzc/121022162554.htm

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[NBC Sports: Hardball Talk] - Giants to face rotation dilemma in World Series

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Source: http://sportspyder.com/teams/new-york-yankees/articles/7594712

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Why Greg Smith left Goldman Sachs

Greg Smith wrote the essay that echoed across Wall Street like a thunderclap.

Smith was a vice president at Goldman Sachs until March. He announced his departure from the investment bank with a blistering essay in The New York Times, accusing Goldman of routinely deceiving clients and relentlessly pursuing profit at the expense of morality.

And he struck a nerve. The essay, on the Op-Ed page of The Times, went viral in the financial world and beyond. Smith was praised for uncloaking corruption that was crying out to be addressed, and also derided as a disgruntled employee.

Goldman Sachs denies Smith's allegations about deceiving clients. The bank says it took his concerns seriously, thoroughly investigated them, and found no evidence to support them.

Smith's book, "Why I Left Goldman Sachs," is being released Monday. It's a window into a company that is notoriously tight-lipped, with stories about a swaggering place where interns arise for 5 a.m. meetings and business trips mean slapping down $150 for one person's dinner.

What Smith hopes to do, he says, is educate people about how Wall Street works, and fuel a public conversation about what went wrong ethically, and how to fix it. The practices that caused the financial crisis, he says, were never really resolved; they're just lying dormant.

Smith, 33, gave his first text interview to The Associated Press. Excerpts have been edited for clarity and length.

Q: Tell us about March 14, the day you left Goldman. You were working in the London office, and you say you had already cleaned out your desk and had been told the essay would go online at 7 a.m. your time.

A: I get up at 6 a.m., and I type a very heartfelt email to nine people in Europe, including the CEO of Goldman Europe, and express in very personal terms why I'm leaving. I talk about exactly what I thought was wrong with the place, this obvious deceit of clients.

Within five minutes I get an email back from someone on the management committee in Europe who says, "I'm really surprised to hear this. I'm in London today. I'd love to meet with you." I get two voice mails from two other people. And then at 6:57 or 6:58, the piece comes online.

Q: What did the bank do?

A: My work BlackBerry stayed on for about three more hours, and I started getting emails from clients who were saying, "We completely agree with you, we don't trust Goldman Sachs, we do business with you guys with a 'buyer beware' attitude." I started getting text messages from Goldman managing directors who were supportive as well. And Goldman reached out to me in formal fashion and said, "We're sorry to hear you resigned; we'd like to air these concerns out."

Q: The bank denies everything you've charged about its ripping off clients.

A: The thing that disappoints me most is that management is denying there's a problem. Why not try to repair the trust instead? Clients are telling you they don't trust you. There's been an SEC fraud suit that was settled for half a billion dollars.

(The Securities and Exchange Commission accused the bank of selling investments to clients when the bank believed the investments were going to fail. Goldman paid $550 million. It remains the largest SEC penalty paid by a Wall Street firm.)

I'm not some lone voice who thought there was a problem, a change from a client fiduciary model (doing what's best for the client) to use-the-client-to-extract-wealth model. It's a problem that many, many of my colleagues felt and that the public feels as well, borne out in SEC suits and congressional testimonies and clients saying publicly that they don't trust us.

Q: Were you just disgruntled? Maybe you didn't get the bonus or the promotion you wanted?

A: I was actually doing well in my career at Goldman. My bonus, I was told I outperformed my peers by 10 percent. I'm a competitive person, and my goal was to get promoted, and I was told by multiple partners that I was two years away from getting promoted. So it certainly was a goal of mine. And on the compensation side, I was earning a lot of money and had a very good living, so I was grateful for what I was earning. It allowed me to have a good life and to support my family and to do things that I thought were valuable.

Q: But you were at Goldman for almost 12 years, if you start with your summer internship in 2000. Weren't there times when you should have stood up, should have said something about what you thought was morally wrong?

A: I actually made a conscious decision not to sell toxic deals to clients. I didn't think it was the right thing to do, but I also saw the idea that if clients' trust is being burned and they're getting blown up, you're not going to have a career for very long.

Now that does not mean I was not part of a system that was doing things that were unethical. In the book, I try to show some of the conflicts I noticed that gave me pause. For many years, I gave the firm the benefit of the doubt.

It absolutely could have happened quicker. But one can always see things earlier and sooner.

Q: OK, but isn't the purpose of any capitalist company to make money? You certainly made a lot of money at Goldman. (Smith says he made in the "high hundreds of thousands of dollars" in his best years but declines to be more specific. His publisher declines to say what he was paid for the book.)

A: Capitalism should be where everyone competes hard and makes money, in an environment where there is fair play and competitiveness. Right now the system is stacked against everyone else in favor of the banks.

It's a little like a casino. A real casino is regulated and there are cameras everywhere and the casino cannot see your cards. With Wall Street today, the bank can see what every government, every pension fund, every hedge fund in the world is doing. They can effectively see everyone's cards. Then, instead of facilitating the client's will, they're trying to get the client to facilitate their will.

Q: What do you hope to accomplish with your book?

A: People know there's this huge conflict, and that things are being done that are unethical but are not necessarily illegal. But nobody can put their finger on exactly what the problem is. My goal with the book was to write it to a general reader who knows nothing about finance. By the time someone reaches the end of the book, they can say, "I can now speak more intelligently about where the conflicts of interest are, and I can lobby my congressman or I can speak about it more." If people are not educated about what the issues are, they're powerless. That was the problem with Occupy Wall Street ? they didn't know what they were protesting.

Q: The banks are going to say any bad practices were caused by just a few bad actors, and that those guys are gone.

A: This is not some conspiracy of five people sitting in a room plotting to destroy the world. This is far more boring. This is where people have created a perverse incentive system.

If someone can overcharge a client by a million dollars, their leaders are going to say, "Great job, we just made an extra million dollars off this pension fund."

Q: So the endemic part is that people don't speak up?

A: People don't like being asked or compelled to make morally dubious decisions. But unfortunately a lot of people's livelihoods are tied up in this, and it's not an easy thing to unwind. Their lives are caught up in this system where they're sending their kids to private schools ? it's almost like the machine for them is working so well that there's no way to undo it unless you want to change your lifestyle.

Q: Why should we care about what happens on Wall Street?

A: You see a lot of commentary that Wall Street is just rich people gambling with other rich people's money. I want people to know that it ultimately affects everyone. In 2008, banks had to be bailed out and that hits taxpayers. If you're a teacher or a fireman or a charity, and you have an investment fund that is trading with Wall Street, and Wall Street is not being held accountable and behaving ethically, then that directly impacts everyone.

Q: What about the reaction of your family and friends to all this? You didn't tell them about the essay beforehand.

A: No, my mother would have been really upset, and frankly my mother is still very upset. She's mostly worried about how I don't have a job right now. For my parents' generation, the idea of stability is very important, while my generation is a little more idealistic about wanting to actually change things, even if it involves some kind of personal risk. It took me a while to show my mother that I was actually very proud of this.

Source: http://news.yahoo.com/why-greg-smith-left-goldman-040638006.html

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Buzzy or Bust? Campaign Slogans Stump Some Voters

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